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In contrast, MR leverages genetic variants as IVs to estimate the direct effect of an exposure on an outcome, minimizing confounding and reverse causation

- regulate e-cigarettes prices through taxation and World Health Organisation (WHO) Framework Convention Tobacco Control protocol on illicit trade in tobacco products

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Retailers are mandated to register as retail merchants and are responsible for diligently collecting and remitting the applicable taxes

See Brands of Smokes in Canada Price Price plays a major role when choosing cigarettes in Canada