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The key is following a gradual titration schedule that increases every four weeks rather than jumping directly to higher doses

doi:10.1007/s00109-016-1488-y Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JHS

demonstrated that long-term GHRH analog administration in aging adults produced sustained increases in GH secretion and IGF-1 levels along with improvements in body composition (3)

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For example, a poorly placed injection that misses the target ligament is unlikely to help and could even cause unintended tissue irritation