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In addition, GPX 4 neuron-induced knockout (GPX 4 NIKO) mice showed motor neuron degeneration, ALS-like paralytic symptoms and spinal motor neuron death (Evans et al., Multiple studies have demonstrated the treatment of ALS by inhibiting iron death in motor neurons

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This endogenous compound plays a fundamental role in cellular defense mechanisms and has been extensively studied for its involvement in oxidative stress management and cellular homeostasis

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mTOR activates lipogenesis by inducing SREBP-1c activation (411)

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