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Phosphoinositide 3-Kinase/Akt signaling and redox metabolism in cancer [J]

[DOI] [PubMed] [Google Scholar] 100.Matuz-Mares D., Hernndez-Vzquez A., Riveros-Rosas H., Guinzberg R., Quesada-Lpez T., Crabez-Trejo A., Mora O., Pia E

3.5 Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship

Finally, the fourth mechanism entails target modification, which can occur through mutations, enzymatic alterations, and replacement 19,64,65

SM, CY and SI were responsible for acquisition of the data and HS was responsible for analysis and interpretation of data

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