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In contrast, secondary metabolites are compounds that are not needed for life, usually not only possessing a wide range of biological functions but also having special mechanisms of action (Li et al., 2021)

Immunologic encounters and microbial clearance mechanisms, in general, involve phagocytosis with ROS, and clearance by RNS and by apoptosis, while cytokines, such as TNFa, IL-4 and IFNy evoke ROS and RNS, directly and indirectly, via signaling pathways

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LiuCGuoHDainJAWanYGaoXHChenHDet alCytoprotective effects of a proprietary red maple leaf extract and its major polyphenol, ginnalin a, against hydrogen peroxide and methylglyoxal induced oxidative stress in human keratinocytes

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Because vascular relaxation is a critical process to maintain blood pressure (143), evidence indicates that arsenic exposure can contribute to hypertension (one of the key characteristics of the MS) by disrupting NO signaling and K + currents in the endothelium and vascular smooth muscle cells