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Another systematic review of 15 studies confirmed the high diagnostic accuracy of CSF NfL levels in separating PD from APS 100

10.1016/j.semnephrol.2018.01.008 62 LiJ.LiY.IveyK

Blood 134:5034

SCD is characterized by intravascular hemolysis, driven by the polymerization of mutated hemoglobin within red blood cells (RBCs), leading to vascular inflammation, organ damage, and heme toxicity

This assay has critical importance in the identification of pathological seeds and is currently under intense study to be used as a biomarker for the diagnosis of synucleinopathies [103, 104]

Singh S, Granberg D, Wolin E, Warner R, Sissons M, Kolarova T, et al