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Conclusion Pregabalin treatment induced significant reproductive toxicity in rats, characterized by decreased body and testicular weights, increased oxidative stress, inflammation, and apoptosis, accompanied by disruption of the hypothalamic-pituitary-gonadal axis

It may mitigate cell damage in the liver

Therefore, a better understanding of the dysregulation of the antioxidant KEAP1-NRF2 activity in ALS could help to develop novel therapeutic strategies able to halt disease progression, prolonging patients survival

L-asparaginase therapy for leukemia and other malignant neoplasms

doi: 10.1016/j.gendis.2020.11.019 [DOI] [PMC free article] [PubMed] [Google Scholar] 98.Sato M, Kusumi R, Hamashima S, et al

Sulfur from sulfur-containing amino acids, namely cysteine, is also incorporated into tRNAs known as tRNA thiolation