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A lipid nanocomposite modified with apolipoprotein A-I, its mimetic peptide 4F, and angioendothelin-2 crosses the BBB, targets microglia, eliminates amyloid-, and inhibits tau phosphorylation, which significantly improves AD pathology (Han et al., 2022)

Bulk RNA sequencing revealed that gene expression changes were most pronounced in the MBH, where RAMP1/3 KO mice treated with sCT showed extensive differential expression of over 1,700 genes, while WT mice exhibited comparatively minor transcriptional shifts

Excess adipose tissue particularly visceral fat is associated with reduced testosterone levels and impaired fertility in men, making effective weight management especially relevant to male health