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Similarly, Piezo1-mediated Ca 2+ influx enhances osteoblast differentiation and vascular remodeling, supporting musculoskeletal and cardiovascular health (2426)

Importantly, recent clinical perspectives have highlighted a significant overlap between ALD and metabolic liver disease, termed Met-ALD, which describes patients with both alcohol consumption and underlying metabolic risk factors ( 4 Zebrafish models for mechanistic insights into drug-induced liver injury and phytochemical protection Drug-induced liver injury (DILI) represents a significant clinical challenge, arising from the direct or indirect hepatocellular damage caused by pharmaceuticals or their metabolites ( via the CYP450 system, generating reactive intermediates that may form protein adducts or stimulate excessive production of reactive oxygen species (ROS), triggering downstream events like lipid peroxidation, mitochondrial dysfunction, and endoplasmic reticulum stress that collectively led to hepatocellular damage (Russmann et al., 2009)

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O 2 - can release iron ions under stress conditions from the iron-sulfur of proteins, participating in the Fenton reaction and converting H 2 O 2 to OH (40)