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While the causes of this condition are complex, recent research has suggested that excess vitamin B12 intake may play a significant role

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Furthermore, 6 days of high fat diet in mice suffice to dramatically decrease the levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in the arcuate nucleus (13) while short term overfeeding of normal weight mice can lead to an increase of leptin resistance (14)

The peer-reviewed literature is also concentrated within a single research group (Watowich lab, University of Texas at Austin) and its industry partner Ridgeline Therapeutics, with limited independent replication to date

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