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However, to our knowledge, only one study has assessed the effect of TNF- on GPX3 expression and shown that, in adipose tissue, GPX3 expression is markedly decreased by TNF-, in agreement with our observation 55

Restoring IGF-1 by administering it seems to have promising effects, at least in rodent studies, but large-scale human data are missing to date (Fig

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[xxii] Kuratsune, H., Yamaguti, K., Lindh, G., Evengrd, B., Hagberg, G., Matsumura, K., Iwase, M., Onoe, H., Takahashi, M., Machii, T., Kanakura, Y., Kitani, T., Lngstrm, B., & Watanabe, Y