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4 Stress homeostasis and drug resistance 4.1 Redox homeostasis Tumor cells can enter a reversible drug-tolerant persister (DTP) state to avoid chemotherapy and targeted drug attack by a mechanism different from tumor resistance through genetic mutations

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Meta-analyses We pooled the combined OCAC and UKBB summary association data (per-allele odds ratios, ORs) with the combined BRCA1 and BRCA2 PV carrier summary association data (per-allele hazard ratios, HRs) by fixed-effects inverse-variance weighted meta-analysis using METAL 116 to give per-allele relative risks (RRs, a combination of population-based ORs and BRCA1 / 2 carrier HRs) (Fig

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