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Typical features of TME include moderate acidity (pH 6.57.0), excessive secretion of reactive oxygen species (such as H 2 O 2 ), and reducing molecules (such as glutathione and GSH) ( 2.3.1 pH-responsive NDDS Even when oxygen is plentiful, tumor cells tend to metabolize glucose through glycolysis rather than efficient oxidative phosphorylation

J Ethnopharmacol 323:117718 Chen Q, Xu Z, Li X, Du D, Wu T, Zhou S, Yan W, Wu M, Jin Y, Zhang J (2021) Epigallocatechin gallate and theaflavins independently alleviate cyclophosphamide-induced ovarian damage by inhibiting the overactivation of primordial follicles and follicular atresia

SIRT1 is part of a family of proteins called sirtuins, known as longevity genes. It uses NAD+ as a fuel source to repair DNA, reduce inflammation, and improve stress resistance