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Other transient effects like flushing or a mild headache may also occur shortly after injection but tend to resolve quickly on their own

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So while this research found that many participants reported increased appetite in relation to taking supplements, it didn't attempt to determine whether or not thats objectively true (or why), or with which dietary supplements it might occur

For this reason, there is no established Tolerable Upper Intake Level (UL), meaning there's no known toxic dose for healthy individuals

(Hematological and other disorders as causes)

Vitamin B12 is considered safe at high doses since it is water-soluble