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J Diabetes Complications

Science 334 , 10861090, (2011)

Holotranscobalamin (holoTC, or active b12) Another useful test is the holoTC test (or active-B12 test), which measures the portion of B12 bound to transcobalamin

This is clinically relevant because obesity itself is associated with numerous health conditions that might influence treatment tolerance, including metabolic syndrome, cardiovascular disease, sleep apnea, and hepatic steatosis

Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed