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Description

How to fix a broken protein: restoring function to mutant human cystathionine beta-synthase

Mikulec, F

Schoonjans K, Peinado-Onsurbe J, Lefebvre AM, Heyman RA, Briggs M, Deeb S et al

doi: 10.1016/j.foodchem.2020.128784 18

The heightened sensitivity of mutant cells is confirmed by siRNA targeting GLUL and GLS , and in the LIM1215 panels, despite LIM1215 G12V displaying a narrower synergistic window