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As a potent antioxidant, NAC inhibits excessive autophagy possibly through scavenging ROS and attenuating the oxidative stress in the small intestine (Fig

In TC, it was demonstrated that high-mobility group box 1 (HMGB1) mediates autophagy, which promotes NIS degradation via ROS/AMPK/mTOR pathway [232], revealing the cell death-modulating role of ROS

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10.1146/annurev.neuro.22.1.123 Annu

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Conclusions During involution, the regulation of organic acids suggests reduced Krebs cycle activity, indicating a transition from high biosynthetic to catabolic activity