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A: There's no strong human evidence that it directly "burns fat" through thermogenesis or lipolysis pathways, the way true fat-loss drugs aim to do

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For best results, use it twice a week or 4-5 day intervals

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Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study

The tolerability of myeloablative L-PAM+BSO in our pediatric phase I study taken together with the preclinical data presented here support the feasibility of a phase I trial of L-PAM+BSO in MM