chac1 glutathione L-2-Hydroxyglutarate sensitizes ferroptosis through ATF3/CHAC1-mediated degradation in hepatocellular carcinoma Mammalian proapoptotic factor ChaC1 and

Mammalian proapoptotic factor ChaC1 and its homologues function as glutamyl cyclotransferases acting specifically on glutathione EMBO Reports Springer Nature Link Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF CRE Regulatory Element ScienceDirect CHAC1 degradation of glutathione enhances cystine starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2 eIF2 ATF4 pathway Oncotarget Dysregulated lipids homeostasis disrupts CHAC1 mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer ScienceDirect Transcriptomic analysis of the effect of (E) 3 (3,5 dimethoxyphenyl) 1 (2 methoxyphenyl) prop 2 en 1 one (DPP23) on reactive oxygen species generation in MIA PaCa 2 pancreatic cancer cells Genes & Genomics Springer Nature Link Frontiers The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications

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