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This study demonstrated encouraging antitumor activity in therapy-refractory mUC treated with paclitaxel plus high-dose anti-CTLA-4 and suggests immune induction may still be possible after failure to anti-PD-(L)1 therapy

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Mild soreness or redness at the injection site may occur but usually subsides within hours.

One hotspot mutation, AKT1 E17K, significantly increases the affinity of AKT for PtdIns(4,5)P2, which activates AKT1 and promotes downstream signaling through its pathological localization to the plasma membrane (106, 107)

The cellular metabolism seemed to deviate from glycolysis to lipid and amino acid utilization, increased TCA-cycle activity, and respiration

Metabolism of Ergothioneine ( EGT ) Studies have shown that Ergothioneine ( EGT ) cannot be synthesized in animals, but it has been clearly shown in plants and microorganisms that histidine, the sulfuratom, and the methyl groups of methionine can be incorporated into thioneine