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Since GSH alone is not effective in the reduction of disulfide bonds, cross-reactions with Trx, which has protein disulfide isomerase activity, may occur

doi: 10.1056/NEJMoa2012971 17 FischerKAl-SawafOBahloJFinkAMTandonMDixonMet al

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Large amounts of DAMPs, including cytokines and inflammatory modulators released from glioma cells that undergo ferroptosis, evokes an intense dysfunctional immune response and recruits numerous immune cells[176]