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Cells were then enzymatically processed to single cells and expression of the cell phase-specific fluorescent signals - in DAPI-neg cells analyzed by flow-cytometry

ACS Chem Neurosci 11:20452047

showed that glutathione reductase (GR) activity, was lower in hyperthyroid patients.95 In another investigation it has been observed that oxidative stress occurred in liver tissue of hyperthyroid animals probably due to impaired antioxidant defense mechanisms.96,97 As antithyroid drugsinduced hepatotoxicity is deteriorated in experimental models with defected liver protective mechanisms,41,51 the question arises if GD (the disease which antithyroid drugs are prescribed against) can sensitize individuals to the antithyroid medications' adverse hepatic effects (Fig