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Silk fibroin has emerged as a promising biomaterial in nanoparticles due to its versatile functionalityhigh mechanical strength, flexibility, low immunogenicity, biodegradability, and biocompatibility (Xiaodan et al., 2016), films (Ma et al., 2025), hydrogels (Kaewchuchuen et al., 2024), powders (Rajkhowa et al., 2012), and micro- or nanoparticles (Roamcharern et al., 2025)enabling broad applications in manufacturing and rational drug delivery design