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The third group of chemotherapeutics is formed by anti-mitotic agents, which act on microtubules

In a study of triple-negative breast cancer (TNBC), it was found that when combined with the SLC7A5 blocker JPH203 and an anti-programmed cell death 1 (PD-1) antibody, it significantly inhibited cell proliferation, invasion, and migration, increased infiltration of CD8 + T cells, and suppressed tumor immune escape [106, 107]

These proteases can cleave inactive forms of transcription factors, converting them into their active forms, which can then bind to DNA and regulate gene expression

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References Pickart L

A relative decrease in aconitase activity in the autism cerebellum is an important new finding, suggesting a functional consequence of oxidative stress in this region