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(2010), akin to the tendon-to-bone healing study of Krivic et al

Three points deserve attention first

At 68 weeks, participants receiving the cagrilintide-semaglutide combination achieved a mean body weight reduction of 22.7% under the trial product estimand

Bone Tissue: Bone healing is facilitated by stimulation of osteoblast activity and improved callus formation

doi:10.1016/j.arthro.2021.02.043 Feroe AG, Clark SC, Hevesi M, et al

When administered together, their mechanisms converge to amplify appetite regulation, energy intake reduction, and glycemic improvements, exceeding the individual effects of monotherapy by acting on complementary neuroendocrine circuits regulating body weight and metabolism 1-3