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K., Crothers, K

G-jZ: Investigation, Writing original draft

Although chlorpheniramine maleate and cetirizine hydrochloride have tolerable side effects, they induce severe side effects on chronic use such as hepatitis and cholestatic jaundice

The benzyl alcohol in bacteriostatic water inhibits bacterial growth, keeping the solution safe for multi-dose use over approximately 28 days

In the following sections, we delineate the key considerations that drive the chemical design of protein-based therapeutics and describe the various design strategies that have led to ~350 approved drug products (Supplementary Tables S1S3)