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While curcumin supplementation in dogs appears to significantly reduce the expression of genes associated with inflammation, 53 its overall effect on pain and mobility in dogs with osteoarthritis has produced variable results, exhibiting improvements in subjective pain assessments in some cases of dogs with osteoarthritis, but not exhibiting reliable objective improvements in mobility

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Factors that can deplete glutathione include poor diet, stress, environmental toxins, and aging

The opposite results were seen by piperonyl butoxide, which is an inhibitor of CYPs P450 metabolism

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[DOI] [PubMed] [Google Scholar] 236.Li JM, Shah AM