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This review could be useful for basic research, pharmacological development, and therapeutic applications of APS in the management of MAFLD

Iron in the human body is primarily derived from dietary sources, which include two absorbable forms: heme ironderived from hemoglobin and myoglobin in red meatand non-heme iron, predominantly found in plant-based foods such as vegetables and cereals, which is released during digestion (Li et al

B.Penagos-PuigA.Ramrez-JarqunJ

doi: 10.1038/S41416-020-01156-1 11 KapitanMNiemiecMJSteimleAFrickJSJacobsenID

It acts prominently on nitric oxide (NO) signaling , counteracting the damaging effects of NO inhibition (e.g., L-NAME) and modulating eNOS through the upregulation of antioxidant enzymes (e.g., HO-1)