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Post-injection care is straightforward: Stay hydrated for the remainder of the day Avoid rubbing or massaging the injection site aggressively Apply a cold compress if swelling or soreness develops at the injection site Monitor for signs of allergic reaction (hives, difficulty breathing, dizziness) for at least 30 minutes Contact your provider or seek emergency care if you experience chest tightness, significant swelling, or breathing difficulty Strenuous exercise can resume the same day for most patients, though some prefer to wait until the following morning if injection-site soreness is noticeable

The multiple phosphoinositides that result can activate key signaling proteins, including RAL, RAC, RHO, FADK, AKT, PKC and calmodulin (CALM), that signal downstream events in the pathways of inflammation, antioxidant responses, stress responses, cell movement (cancer-cell invasion), and endocytosis

Looking ahead, the development of biomarker-guided multimodal therapies is a promising direction

369,370,371 Viral RNA has the capability to induce the release of IL-1 and IL-18 by activating inflammasomes through MAVS and NLR

doi: 10.1146/annurev-immunol-042617-053010 59 Meessen-PinardMLe CoupanecADesforgesMTalbotPJ

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