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Priddy LB, Chaudhuri O, Stevens HY, Krishnan L, Uhrig BA, Willett NJ, et al

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1:500) was incubated for 1 h at room temperature

3 Ferroptosis in RCC 3.1 Ferroptosis signaling pathway and RCC 3.1.1 HIF-iron metabolism pathway involved in ferroptosis and RCC ccRCC is associated closely with mutations in the VHL gene that lead to the activation of HIF-1 and HIF-2 via a pseudohypoxia mechanism, resulting in the transcription of genes involved in tumor progression (77), and as HIF-1 mediates the cellular upregulation of TfRC and heme oxygenase (HO) expression, promoting cellular iron accumulation (78, 79)

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