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doi: 10.3389/fnmol.2023.1155175 Received 31 January 2023 Accepted 27 April 2023 Published 17 May 2023 Volume 16 - 2023 Edited by Khurshid Ahmad, Yeungnam University, Republic of Korea Reviewed by Nemat Ali, King Saud University, Saudi Arabia

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Altered domain structure of the prion protein caused by Cu 2+ binding and functionally relevant mutations: analysis by cross-linking, MS/MS, and NMR