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Many immunomodulatory drugs also inhibit TGFB, reduce plasma levels of IL1 and IL1B, and prevent activation of NFkB

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Nature , 406 (6797), 747752

MCAS is often found in individuals with hypermobility syndromes (EhlersDanlos syndrome), postural orthostatic hypotension (POTS) as well as chronic inflammatory response syndrome (CIRS) and tick-borne illnesses (Lyme disease and co-infections)

This ability to mitigate inflammation without the gastrointestinal risks associated with traditional nonsteroidal anti-inflammatory drugs (NSAIDs) makes it a potentially valuable alternative for pain and inflammation management during recovery

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