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However, in the development of visually significant symptoms or with progression to macular hole, the most successful treatment is vitrectomy

Beyond Wilsons disease, other states of impaired copper handling warrant caution including advanced liver disease

Int J Biol Macromol 159:870876

Power analysis and advanced statistics can potentially help to reduce the number of replicates ( While pseudo-replication due to the re-use of animals can be compensated for using Bayesian statistics ( Pagurus bernhardus ( The number of replicates should then be carefully decided based on such previous experiments with the chosen model organisms