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Lacombe, V., Chabrun, F., Lacout, C

Aim to include multiple iron- and B12-rich sources throughout the week, combining them with enhancers (like vitamin C) and avoiding inhibitors (like tea or coffee directly with meals) for optimal benefit

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For patients whose symptoms significantly impact quality of life, healthcare providers may consider evidence-based pharmacologic options such as certain SSRIs/SNRIs, gabapentin, oxybutynin, or fezolinetant (FDA-approved for moderate to severe vasomotor symptoms)

Whilst vitamin B12 toxicity is exceptionally rare due to its water-soluble nature, very high levelsparticularly from mega-dose supplements or frequent injectionshave been associated with certain adverse effects, most notably skin reactions

And now its emerging as a powerful tool in longevity science and functional medicine, thanks to its ability to indirectly boost NAD+ levels by slowing the rate of depletion