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The pathomechanisms of these diseases are multifactorial (Fig

Bibcode:2010OExpr..1816406T

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70 Notably, organotypic hippocampal slice cultures with ferroptosis-specific inhibitors were shown to prevent neuronal death and decrease hemoglobin-induced iron accumulation, suggesting a pathogenic role of ferroptosis in intracerebral hemorrhage

While eumelanin shows photoprotective capacity against ultraviolet (UV) [15], in contrast pheomelanin is weakly photoprotective and highly phototoxic, enhancing the UV-induced production of reactive oxygen species (ROS) and further damage of cells [16]

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