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As PD progresses, Lewy pathology ascends to the midbrain (particularly the SNc) and accounts for development of motor features

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The liver Phase II detoxification involves conjugation reactions, where toxins are linked to substances like glutathione to facilitate their excretion (60)

Through comprehensive intestinal microbiome ecological restructuring, PU efficaciously reduces circulating lipopolysaccharide and diamine oxidase (DAO) concentrations, ameliorating inflammatory responses and alleviating metabolic dysregulation in DN models

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Panels b, h, j and l insets show the bottom (1), middle (2) and top (3) parts of the villus (red dashed frames on the villus image)