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Early preclinical studies showed that daratumumab effectively induced ADCC in a dose-dependent manner [30] and recent studies with isatuximab suggest that ADCC may be a more dominant effector mechanism than originally thought [24, 31]

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There is insufficient safety data for either compound during pregnancy, and animal studies with GLP-1 agonists showed adverse fetal effects

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After co-culture, the cells were stained with APC-Cy7-anti-CD14 (BioLegend) prior to fixation and analyzed using the LSRFortessa (BD)

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