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These prevalence data 15 from a Polish population have not, however, been confirmed by other investigators 15 in patients from Japanese populations or US white populations

To understand how antioxidants fit into the bigger picture, you can also explore our guide on why we need antioxidants

An initial study with a limited sample size (39 HAPE patients and 43 controls) revealed no role of CYBA in HAPE pathogenesis in Caucasians, 119 but a larger Indian cohort (150 HAPE patients and 180 controls) linked CYBA (rs4673 and rs9932581) and GSTP1 (rs1695 and rs1138272) to elevated circulating 8-iso-prostaglandin F2 in HAPE, potentially contributing to HAPE susceptibility