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Liuyang S, Wang G, Wang Y, He H, Lyu Y, Cheng L, et al

Influenza a virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages

Frataxin deficiency is associated with imbalances in iron-sulfur containing proteins, mitochondrial respiratory chain dysfunction and lower ATP production, and accumulation of iron in the mitochondria, which increases oxidative stress and oxidative damage to macromolecules of the respiratory chain (77)

These factors frequently cause neurons to be under stress, which in turn causes cytotoxic events such as an increase in excitotoxicity, ROS, synaptic dysfunction, ER stress, impaired protein degradation systems, DNA damage, cell cycle re-entry, inflammation, and mitochondrial dysfunction (Seward et al., 2013)

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Genistein protects against acute pancreatitis via activation of an apoptotic pathway mediated through endoplasmic reticulum stress in rats