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Late disseminated phase often starts 3 to 12 months after the bite

A balanced diet and adequate hydration to support the body's own glutathione production Complementary topical treatments - vitamin C serums, niacinamide, and prescribed brightening agents can extend results between sessions The longevity of results varies by individual

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Retinoids work by binding to retinoic acid receptors in the nucleus, directly altering gene transcription

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This overview synthesizes key findings on its cytoprotective mechanism and experimental applications in wound healing, tendon repair, gastrointestinal models, and angiomodulation