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The elevation of plasma formaldehyde in the Aldh2*2 KI mice is considered to be caused by a combination of ALDH2 dysfunction and ADH5 downregulation in the liver, as the two enzymes are responsible for formaldehyde detoxification [89]

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Mol Immunol 149:6676 Xiong M, He Q, Wang J, Lai H (2011) Astragalosides reduce cisplatin ototoxicity in guinea pigs

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