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Leyden JJ, Stephens TJ, Finkey MB, Appa Y, Barkovic S

y.et al (2013)

Pediatr Surg Int

Elevated SAM levels inhibit MAT activity, thereby reducing SAM synthesis and maintaining SAM homeostasis

Noctor G, Mhamdi A, Chaouch S, Han Y, Neukermans J, Marquez-Garcia B, Queval G, Foyer CH

Other targeted ALS pathways include neurotrophic factors, oxidative stress, neuromuscular junction and axonal integrity, mitochondrial function and energy expenditure, RNA metabolism, and the gutbrain axis (Fig