chac1 glutathione (GSH) depletion by results in a more oxidizing The CHAC1-inhibited Notch3 pathway is

The CHAC1 inhibited Notch3 pathway is involved in temozolomide induced glioma cytotoxicity ScienceDirect Frontiers Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death Identification of Juglone, a 'first in class' inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast based high throughput screens bioRxiv Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF CRE Regulatory Element ScienceDirect Transcriptomic analysis of the effect of (E) 3 (3,5 dimethoxyphenyl) 1 (2 methoxyphenyl) prop 2 en 1 one (DPP23) on reactive oxygen species generation in MIA PaCa 2 pancreatic cancer cells Genes & Genomics Springer Nature Link Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC Nature Communications

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