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Nelfinavir induces cytotoxicity towards high-grade serous ovarian cancer cells, involving induction of the unfolded protein response, modulation of protein synthesis, DNA damage, lysosomal impairment, and potentiation of toxicity caused by proteasome inhibition

6 Conclusion This review highlights the pivotal role of immune dysregulation in the pathogenesis of CKD-MBD, demonstrating how chronic inflammation and aberrant immune responses contribute to bone loss, VC, and increased cardiovascular risk in CKD patients

At 3 nmol/kg SC, wild-type mice lost approximately 3.4 g body weight versus no significant loss in vehicle-treated controls

Autophagic flux modulation by Wnt/-catenin pathway inhibition in hepatocellular carcinoma

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