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The intertwined roles of PERK and IRE1 in angiogenesis, EMT, dormancy, and therapy resistance emphasize why indiscriminate UPR inhibition is unlikely to succeed clinically and why pathway-selective, context-aware strategies are needed

doi: 10.1002/jps.22285, PMID: [DOI] [PubMed] [Google Scholar] 229.Wen Z, Yan Z, Hu K, Pang Z, Cheng X, Guo L, et al

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Alcohol reduces immune function, as well, due to the loss of glutathione stores

the dual function of Topoisomerases i.e., catalysis and religation, requires unimpeded reactivities of the cysteinyl residues that bind and affect the inter-subunit interactions of topoisomerase to achieve "global" effects

and (3) BBB monitoring techniques with a focus on clinical utility