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1 Introduction Gliomas are the most common primary malignant tumours of the central nervous system (CNS), accounting for approximately 30% of all primary brain and CNS tumours and 80% of malignant brain tumours ( 7 and O 6 sites of guanine and at the N 3 site of adenine

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Wu H, Chen C, Gu L, Li J, Yue Y, Lyu M, Cui Y, Zhang X, Liu Y, Zhu H, Liao X, Zhang T, Sun F, Hu W

Moreover, although certain peptides exhibit cell-penetrating properties, their translocation efficiency remains generally low, particularly across stringent biological barriers such as the BBB, restricting their therapeutic applicability in hard-to-treat diseases (Table 2)

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