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The authenticity of this article has been validated by uploading the key raw data onto the Research Data Deposit public platform (www.researchdata.org.cn), with the approval RDD number as RDDB2025916508

Hi : HGF inhibitor (Rilotumumab/AMG102 is a human HGF-neutralising antibody from Amgen Inc., Thousand Oaks, CA, USA) 300 g in 200 l PBS IP twice weekly

The male SHR model showed that intestinal flora and its metabolites are closely associated with hypertension-related nephropathy, and the results indicate that reduced levels of SCFAs, inflammatory factor release, and blood pressure disturbances occur in the process (174)