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Follow-up work has examined GHK-Cu's activity on matrix metalloproteinases, proteoglycan synthesis, and glycosaminoglycan production in the dermal extracellular matrix (Simeon et al., Life Sci, 2000

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J Biol Chem 284:3535935367 Roche E, Farfari S, Witters LA et al (1998) Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression