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That is exactly what occurred in this Warning Letter

The laser beam was focused on the specimen surface through an optical fibre and with the help of a low-power He-Ne pilot laser

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Thau et al

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the gold standard for quantifying dihexa in plasma, with a lower limit of quantification typically around 15 ng/mL depending on sample preparation and ionization efficiency

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