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However, if extremely high doses are given for a long time, pyridoxine can cause nerve damage leading to numbness or tingling in the hands and feet (peripheral neuropathy)

It has a more extensive research history including human clinical trials, though efficacy results were insufficient for continued pharmaceutical development

Reference: Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ (2018)

Pregnant or breastfeeding women, and those planning to become pregnant, should not use this treatment

Jeff , who is the clinical nurse who does the treatment, was so charming and actually just pure delight

While experimental findings point to diverse biological actions, mechanisms remain uncertain and outcomes appear context-dependent